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tpc-1 (human ptc cell line)  (BioVector NTCC)

 
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    BioVector NTCC tpc-1 (human ptc cell line)
    Tpc 1 (Human Ptc Cell Line), supplied by BioVector NTCC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/tpc-1 (human ptc cell line)/product/BioVector NTCC
    Average 90 stars, based on 1 article reviews
    tpc-1 (human ptc cell line) - by Bioz Stars, 2026-02
    90/100 stars

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    human ptc cell line tpc-1  (Johns Hopkins HealthCare)
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    MFAP2 was overexpressed in <t>PTC</t> and provided a great prognostic and diagnostic value in PTC. ( A ) MFAP2 expression levels were greater in PTC tissues than in normal thyroid tissues in TCGA dataset. ( B ) The overexpression of MFAP2 in PTC was verified in our validated cohort by using qRT-PCR. ( C ) MFAP2 was upregulated in 78 PTC tissues compared with corresponding non-tumorous thyroid tissues from our RNA sequencing dataset. ( D ) Heatmap of the differentially expressed genes in TCGA database, based on the adjusted p-value. ( E ) Volcano map of genes expressed <t>in</t> <t>TPC.</t> ( F ) Disease-free survival analysis of MFAP2 expression levels in TCGA database using Kaplan-Meier analyses. ( G ) ROC curve analysis of MFAP2 expression levels in PTC patients. ***p<0.001, ****p<0.0001.
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    MFAP2 was overexpressed in PTC and provided a great prognostic and diagnostic value in PTC. ( A ) MFAP2 expression levels were greater in PTC tissues than in normal thyroid tissues in TCGA dataset. ( B ) The overexpression of MFAP2 in PTC was verified in our validated cohort by using qRT-PCR. ( C ) MFAP2 was upregulated in 78 PTC tissues compared with corresponding non-tumorous thyroid tissues from our RNA sequencing dataset. ( D ) Heatmap of the differentially expressed genes in TCGA database, based on the adjusted p-value. ( E ) Volcano map of genes expressed in TPC. ( F ) Disease-free survival analysis of MFAP2 expression levels in TCGA database using Kaplan-Meier analyses. ( G ) ROC curve analysis of MFAP2 expression levels in PTC patients. ***p<0.001, ****p<0.0001.

    Journal: Cancer Management and Research

    Article Title: MFAP2 is a Potential Diagnostic and Prognostic Biomarker That Correlates with the Progression of Papillary Thyroid Cancer

    doi: 10.2147/CMAR.S274986

    Figure Lengend Snippet: MFAP2 was overexpressed in PTC and provided a great prognostic and diagnostic value in PTC. ( A ) MFAP2 expression levels were greater in PTC tissues than in normal thyroid tissues in TCGA dataset. ( B ) The overexpression of MFAP2 in PTC was verified in our validated cohort by using qRT-PCR. ( C ) MFAP2 was upregulated in 78 PTC tissues compared with corresponding non-tumorous thyroid tissues from our RNA sequencing dataset. ( D ) Heatmap of the differentially expressed genes in TCGA database, based on the adjusted p-value. ( E ) Volcano map of genes expressed in TPC. ( F ) Disease-free survival analysis of MFAP2 expression levels in TCGA database using Kaplan-Meier analyses. ( G ) ROC curve analysis of MFAP2 expression levels in PTC patients. ***p<0.001, ****p<0.0001.

    Article Snippet: Two human PTC cell lines (TPC-1 and BCPAP) were provided by Prof. Mingzhao Xing of Johns Hopkins University School of Medicine (Baltimore, MD, USA).

    Techniques: Diagnostic Assay, Expressing, Over Expression, Quantitative RT-PCR, RNA Sequencing

    MFAP2 was upregulated in PTC cell lines and induced their proliferation abilities in vitro. ( A ) CCK-8 assays performed in two PTC cell lines. ( B , D ) Colony formation assays in two PTC cell lines and corresponding number of colonies. ( C ) The relative expression of MFAP2 in PTC cell lines. MFAP2 was upregulated in two PTC cell lines (BCPAP and TPC-1) compared to normal thyroid cell line HTORI-3. ( E ) MFAP2 expression levels were lower in Si-MFAP2 groups than in Si-NC group in the two PTC cell lines. **p<0.01, ***p<0.001, ****p<0.0001.

    Journal: Cancer Management and Research

    Article Title: MFAP2 is a Potential Diagnostic and Prognostic Biomarker That Correlates with the Progression of Papillary Thyroid Cancer

    doi: 10.2147/CMAR.S274986

    Figure Lengend Snippet: MFAP2 was upregulated in PTC cell lines and induced their proliferation abilities in vitro. ( A ) CCK-8 assays performed in two PTC cell lines. ( B , D ) Colony formation assays in two PTC cell lines and corresponding number of colonies. ( C ) The relative expression of MFAP2 in PTC cell lines. MFAP2 was upregulated in two PTC cell lines (BCPAP and TPC-1) compared to normal thyroid cell line HTORI-3. ( E ) MFAP2 expression levels were lower in Si-MFAP2 groups than in Si-NC group in the two PTC cell lines. **p<0.01, ***p<0.001, ****p<0.0001.

    Article Snippet: Two human PTC cell lines (TPC-1 and BCPAP) were provided by Prof. Mingzhao Xing of Johns Hopkins University School of Medicine (Baltimore, MD, USA).

    Techniques: In Vitro, CCK-8 Assay, Expressing

    Downregulation of MFAP2 inhibited the migration and invasion abilities in PTC cell lines. ( A , C ) Transwell migration assay in Si-MFAP2 group and corresponding control group in two PTC cell lines. ( B , D ) The Matrigel assay in Si-MFAP2 groups and corresponding control group in two PTC cell lines. The quantitative results of the migration assay were determined from five random fields. The data came from at least three independent experiments. **p<0.01, ***p<0.001, ****p<0.0001.

    Journal: Cancer Management and Research

    Article Title: MFAP2 is a Potential Diagnostic and Prognostic Biomarker That Correlates with the Progression of Papillary Thyroid Cancer

    doi: 10.2147/CMAR.S274986

    Figure Lengend Snippet: Downregulation of MFAP2 inhibited the migration and invasion abilities in PTC cell lines. ( A , C ) Transwell migration assay in Si-MFAP2 group and corresponding control group in two PTC cell lines. ( B , D ) The Matrigel assay in Si-MFAP2 groups and corresponding control group in two PTC cell lines. The quantitative results of the migration assay were determined from five random fields. The data came from at least three independent experiments. **p<0.01, ***p<0.001, ****p<0.0001.

    Article Snippet: Two human PTC cell lines (TPC-1 and BCPAP) were provided by Prof. Mingzhao Xing of Johns Hopkins University School of Medicine (Baltimore, MD, USA).

    Techniques: Migration, Transwell Migration Assay, Control, Matrigel Assay

    Downregulation of MFAP2 prevented EMT while promoting apoptotic rate in PTC cell lines. ( A , B , C , D ) Silencing of MFAP2 promoted apoptosis in PTC cell lines. ( E ) Western blotting showed knockdown of MFAP2 upregulated E-cadherin and downregulated N-cadherin , Vimentin and β-catenin in protein levels. *p<0.05 and ***p<0.001.

    Journal: Cancer Management and Research

    Article Title: MFAP2 is a Potential Diagnostic and Prognostic Biomarker That Correlates with the Progression of Papillary Thyroid Cancer

    doi: 10.2147/CMAR.S274986

    Figure Lengend Snippet: Downregulation of MFAP2 prevented EMT while promoting apoptotic rate in PTC cell lines. ( A , B , C , D ) Silencing of MFAP2 promoted apoptosis in PTC cell lines. ( E ) Western blotting showed knockdown of MFAP2 upregulated E-cadherin and downregulated N-cadherin , Vimentin and β-catenin in protein levels. *p<0.05 and ***p<0.001.

    Article Snippet: Two human PTC cell lines (TPC-1 and BCPAP) were provided by Prof. Mingzhao Xing of Johns Hopkins University School of Medicine (Baltimore, MD, USA).

    Techniques: Western Blot, Knockdown